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Metazoan mechanotransduction mystery finally solved

In a technical tour de force, whole-cell patch clamp in tiny C. elegans touch receptor neurons in vivo is used to directly record currents in response to mechanical force, providing the first direct evidence that specific proteins are mechanotransducers.

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Figure 1: Recording currents in the C. elegans touch-receptor neuron and model of mechanotransduction complex.

Debbie Maizels

References

  1. O'Hagan, R., Chalfie, M. & Goodman, M. Nat. Neurosci. 8, 43–50 (2005).

    Article  CAS  Google Scholar 

  2. Chalfie, M. & Sulston, J. Dev. Biol. 82, 358–370 (1981).

    Article  CAS  Google Scholar 

  3. Ernstrom, G.G. & Chalfie, M. Annu. Rev. Genet. 36, 411–453 (2002).

    Article  CAS  Google Scholar 

  4. Huang, M. & Chalfie, M. Nature 367, 467–470 (1994).

    Article  CAS  Google Scholar 

  5. Driscoll, M. & Chalfie, M. Nature 349, 588–593 (1991).

    Article  CAS  Google Scholar 

  6. Huang, M., Gu, G., Ferguson, E.L. & Chalfie, M. Nature 378, 292–295 (1995).

    Article  CAS  Google Scholar 

  7. Chelur, D.S. et al. Nature 420, 669–673 (2002).

    Article  CAS  Google Scholar 

  8. Goodman, M.B. et al. Nature 415, 1039–1042 (2002).

    Article  CAS  Google Scholar 

  9. Suzuki, H. et al. Neuron 39, 1005–1017 (2003).

    Article  CAS  Google Scholar 

  10. Walker, R.G., Willingham, A.T. & Zuker, C.S. Science 287, 2229–2234 (2000).

    Article  CAS  Google Scholar 

  11. Tavernarakis, N., Shreffler, W., Wang, S. & Driscoll, M. Neuron 18, 107–119 (1997).

    Article  CAS  Google Scholar 

  12. Ainsley, J.A. et al. Curr. Biol. 13, 1557–1563 (2003).

    Article  CAS  Google Scholar 

  13. Kim, J. et al. Nature 424, 81–84 (2003).

    Article  CAS  Google Scholar 

  14. Sidi, S., Friedrich, R.W. & Nicolson, T. Science 301, 96–99 (2003).

    Article  CAS  Google Scholar 

  15. Corey, D.P. et al. Nature advance online publication 13 October 2004 (doi:10.1038/nature03066).

Download references

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Ronan, D., Gillespie, P. Metazoan mechanotransduction mystery finally solved. Nat Neurosci 8, 7–8 (2005). https://doi.org/10.1038/nn0105-7

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