Nature Neuroscience8, 72 - 78 (2004)
Published online: 19 December 2004; | doi:10.1038/nn1376
There is a Corrigendum (March 2005) associated with this Article.
High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections
Christine L Torborg, Kristi A Hansen
& Marla B Feller
Neurobiology Section, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA.
Correspondence should be addressed to Marla B Feller mfeller@ucsd.edu
Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation.
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