Christine Vande Velde and Don W. Cleveland are at the Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. dcleveland@ucsd.edu
Amyotrophic lateral sclerosis is an incurable paralyzing disorder caused by the death of motor neurons in the spinal cord and brainstem. Patients typically die within three to five years. In this issue, Storkebaum and colleagues offer new evidence for VEGF action in motor neuron survival and new hope for direct delivery of VEGF into the nervous system as a therapy for ALS.
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