Sacha B. Nelson is at the Biology Department and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA. nelson@brandeis.edu
In a brainstem auditory nucleus, excitatory synapses from the same presynaptic neuron are shown to cause opposing forms of spike timing−dependent plasticity in projection neurons and GABAergic interneurons at low frequencies, but to cause the same form of plasticity at high frequencies. The net effect is to enhance activation of the projection neurons by relevant stimuli.
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