Brief Communication abstract
Nature Neuroscience 7, 495 - 496 (2004)
Published online: 28 March 2004 | doi:10.1038/nn1219
Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking
Roberto Ciccocioppo1,3, Rémi Martin-Fardon2,3 & Friedbert Weiss2
Epidemiological data suggest that cocaine dependence emerges rapidly, and most cocaine addicts meet criteria for dependence within 1–3 years after onset of drug use. Here we show that in rats, environmental stimuli associated with a single cocaine self-administration experience elicit strong cocaine-seeking that persists for up to one year. In contrast, conditioned stimuli that were associated with a highly palatable non-drug reinforcer elicited modest behavioral responses that extinguished within 3 months.
- Department of Pharmacological Science and Experimental Medicine, University of Camerino, 62032 Camerino (MC), Italy.
- The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA.
- These authors contributed equally to this work.
Correspondence to: Roberto Ciccocioppo1,3 e-mail: roberto.ciccocioppo@unicam.it
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