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Nature Neuroscience 7, 419 - 420 (2004)
doi:10.1038/nn0504-419
Presynaptic NMDA receptors get into the act
Anastassios V Tzingounis1 & Roger A Nicoll1
- Anastassios V. Tzingounis and Roger A. Nicoll are at the Departments of Cellular and Molecular Pharmacology and Physiology, University of California at San Francisco, San Francisco, California 94943, USA. e-mail: nicoll@cmp.ucsf.edu
Abstract
In a new form of synaptic plasticity, depolarization of Purkinje cells increases the frequency of mini GABAergic IPSCs, via glutamate acting as a retrograde messenger on presynaptic NMDA receptors on the terminals of cerebellar interneurons.
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