News and Views
Nature Neuroscience 7, 417 - 418 (2004)
doi:10.1038/nn0504-417
Eph–ephrin promiscuity is now crystal clear
Elena B Pasquale1
- Elena B. Pasquale is at the Burnham Institute, La Jolla, California 92037, USA and the Department of Pathology, University of California at San Diego, La Jolla, California 92093, USA. e-mail: elenap@burnham.org
Abstract
The ephrin subclasses A and B are not thought to interact much with each other's receptors. A study in this issue now shows that ephrin-A5 can signal through the EphB2 receptor, toppling this dogma. The crystal structure of the EphB2–ephrin-A5 complex clarifies the molecular features of this interaction and suggests new hypotheses for the mechanism of ephrin receptor signaling.
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