Nature Neuroscience7, 211 - 214 (2004)
Published online: 24 February 2004; | doi:10.1038/nn1200
Prefrontal responses to drug cues: a neurocognitive analysis
Stephen J Wilson1, Michael A Sayette2
& Julie A Fiez3
1
Stephen J Wilson is in the Department of Psychology, University of Pittsburgh, and at the Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania, USA.
2
Michael A Sayette is in the Departments of Psychology and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
3
Julie A Fiez is in the Departments of Psychology and Neuroscience, University of Pittsburgh, and at the Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania, USA.
Correspondence should be addressed to Stephen J Wilson sjwilson@pitt.edu
The construct of craving has been central to addiction research for more than 50 years. Only recently have investigators begun to apply functional neuroimaging techniques to the study of drug cue reactivity, and a small but growing number of studies implicate a distributed system of brain regions in the pathogenesis of craving. The internal consistency of this burgeoning literature has thus far been disappointing, however, leaving open the question of which brain regions contribute to craving. Here we review neuroimaging studies of cue-elicited craving in the context of a framework drawn from behavioral research indicating that perceived drug use opportunity significantly affects responses to the presentation of drug cues. Using this framework provides a way to reconcile discrepant findings among brain-imaging studies of cue-elicited craving.
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