Article abstract
Nature Neuroscience 7, 136 - 144 (2004)
Published online: 4 January 2004 | Corrected online: 12 January 2004 | doi:10.1038/nn1172
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Stephen C Noctor1, Verónica Martínez-Cerdeño1, Lidija Ivic1 & Arnold R Kriegstein1,2,3
Abstract
Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult cerebral cortex. Using time-lapse imaging of clonal cells in rat cortex over several generations, we show here that neurons are generated in two proliferative zones by distinct patterns of division. Neurons arise directly from radial glial cells in the ventricular zone (VZ) and indirectly from intermediate progenitor cells in the subventricular zone (SVZ). Furthermore, newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate. These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration.
- Department of Neurology, Columbia University College of Physicians & Surgeons, 630 W. 168th Street, New York, New York 10032, USA.
- Department of Pathology, Columbia University College of Physicians & Surgeons, 630 W. 168th Street, New York, New York 10032, USA.
- Center for Neurobiology and Behavior, Columbia University College of Physicians & Surgeons, 630 W. 168th Street, New York, New York 10032, USA.
Correspondence to: Stephen C Noctor1 e-mail: scn8@columbia.edu
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