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Article
Nature Neuroscience  7, 1319 - 1328 (2004)
Published online: 7 November 2004; | doi:10.1038/nn1345

Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain

E S Anton1, 8, H T Ghashghaei1, 8, Janet L Weber2, Corey McCann1, Tobias M Fischer2, Isla D Cheung2, Martin Gassmann3, Albee Messing4, Rudiger Klein5, Markus H Schwab2, 6, K C Kent Lloyd7 & Cary Lai2

1  UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

2  Department of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

3  Department of Physiology, Biozentrum/Pharmazentrum, University of Basel Klingelbergstr. 50, CH-4056 Basel, Switzerland.

4  Waisman Center on Mental Retardation & Human Development, University of Wisconsin-Madison, Madison, Wisconsin 53705-2280, USA.

5  Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18A, 82152 Martinsried, Germany.

6  Max-Planck-Institut für Experimentelle Medizin, Hermann−Rein−Str. 3, 37075 Göttingen, Germany.

7  Center for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.

8  These authors contributed equally to this work.

Correspondence should be addressed to E S Anton anton@med.unc.edu
Neural progenitor proliferation, differentiation and migration are continually active in the rostral migratory stream of the adult brain. Here, we show that the receptor tyrosine kinase ErbB4 is expressed prominently by the neuroblasts present in the subventricular zone and the rostral migratory stream. The neuregulins (NRG1−NRG3), which have been identified as ErbB4 ligands, are detected either in the stream or in adjacent regions. Mice deficient in ErbB4 expressed under the control of either the nestin or the hGFAP promoter have altered neuroblast chain organization and migration and deficits in the placement and differentiation of olfactory interneurons. These findings suggest that ErbB4 activation helps to regulate the organization of neural chains that form the rostral migratory stream and influences the differentiation of olfactory interneuronal precursors.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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