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Brief Communication

Nature Neuroscience 7, 1184–1186 (1 November 2004) | doi:10.1038/nn1334

Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs

Graziella Di Cristo , Caizhi Wu , Bidisha Chattopadhyaya , Fabrice Ango , Graham Knott , Egbert Welker , Karel Svoboda & Z Josh Huang

Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures.