Nature Neuroscience7, 1184 - 1186 (2004)
Published online: 10 October 2004; | doi:10.1038/nn1334
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs
Graziella Di Cristo1, Caizhi Wu1, Bidisha Chattopadhyaya1, 2, Fabrice Ango1, Graham Knott3, Egbert Welker3, Karel Svoboda1
& Z Josh Huang1
1
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
2
State University of New York, Stony Brook, New York 11790, USA.
3
Institute de Biologie Cellulaire et de Morphologie, University of Lausanne, CH 1005 Lausanne, Switzerland.
Correspondence should be addressed to Z Josh Huang huangj@cshl.edu
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.
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