 | Figure 2
Nature Neuroscience
7, 1096 - 1103 (2004)
Published online: 19 September 2004; | doi:10.1038/nn1316
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegansDaniel L Chase, Judy S Pepper
& Michael R Koelle | | | | Figure 2. Gene structure and knockout mutations of dop-1, dop-2 and dop-3.
Coding exons are boxed. Lines below the exon structures show the extent of the genomic region deleted in the indicated allele. Scale bar in upper right represents 1 kb. For dop-1, the vs100 deletion removes sequences encoding most of the seventh transmembrane domain and truncates the protein by changing the reading frame. The in-frame vs101 deletion removes sequences encoding most of the fourth transmembrane domain and the entire second extracellular loop. For dop-2, the vs105 deletion removes the splice acceptor for exon 2 as well as sequences encoding most of the first two transmembrane domains. For dop-3, the vs106 deletion removes 86 base pairs of the promoter along with sequences encoding the first transmembrane domain, the first intracellular loop and most of the second transmembrane domain.
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