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Brief Communication

Nature Neuroscience 6, 911–912 (1 September 2003) | doi:10.1038/nn1101

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

Thomas Blank , Ingrid Nijholt , Min-Jeong Kye , Jelena Radulovic & Joachim Spiess

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus.