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Agrin / MuSK signaling: willing and Abl

Nature Neuroscience volume 6, pages 653–654 (2003)Cite this article

During neuromuscular synapse development, clustering of acetylcholine receptors requires Agrin/MuSK signaling. The non-receptor tyrosine kinases Abl1 and Abl2 are now suggested to be the signals downstream of MuSK leading to receptor clustering.

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Figure 1: Signaling steps in the Agrin/MuSK pathway (a) that lead to AChR clustering and stabilization at the neuromuscular junction.

Erin Boyle

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Author information

Authors and Affiliations

  1. Molecular Neurobiology Program, New York University School of Medicine, New York, 10016, New York, USA

    Steven J Burden

  2. Structural Biology Program at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, 10016, New York, USA

    Stevan R Hubbard

  3. Brain Research Institute, University of Zürich-Irchel, Zürich, CH-8057, Switzerland

    Christian Fuhrer

Authors
  1. Steven J Burden
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  2. Christian Fuhrer
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  3. Stevan R Hubbard
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Correspondence to Steven J Burden.

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Burden, S., Fuhrer, C. & Hubbard, S. Agrin / MuSK signaling: willing and Abl. Nat Neurosci 6, 653–654 (2003). https://doi.org/10.1038/nn0703-653

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