Long-term use of L-DOPA as a treatment for Parkinson disease can induce uncontrollable movements. A new report attributes this side effect to abnormal downregulation of synaptic plasticity.
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Dunnett, S. L-DOPA, dyskinesia and striatal plasticity. Nat Neurosci 6, 437–438 (2003). https://doi.org/10.1038/nn0503-437
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DOI: https://doi.org/10.1038/nn0503-437
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