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Brief Communication
Nature Neuroscience  6, 445 - 446 (2003)
Published online: 31 March 2003; | doi:10.1038/nn1038

Epigenetic sources of behavioral differences in mice

Darlene D. Francis1, Kathleen Szegda1, Gregory Campbell2, W. David Martin2 & Thomas R. Insel1, 3, 4

1  Center for Behavioral Neuroscience, Emory University, Yerkes Research Center, 954 Gatewood Rd., Atlanta, Georgia 30329, USA

2  Transgenic Mouse Core, Emory University School of Medicine, Whitehead Research Building, Atlanta, Georgia 30329, USA

3  Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA

4  Present address: NIMH, 6001 Executive Blvd. Room 8235, MSC 9669, Bethesda, Maryland 20892, USA

Correspondence should be addressed to Thomas R. Insel insel@mail.nih.gov
Inbred mouse strains are classically used to search for the genes associated with behavioral traits, including emotionality. To distinguish genetic and environmental contributions to the expression of adult behavior in mice, we investigated the effects of prenatal (embryo transfer) and postnatal (cross-fostering) environments in two strains of inbred mice with profound and reliable differences in behavior1. Here we report that strain-related behavioral differences may result from environmental factors during development rather than genetic differences between the offspring.


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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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