 | Figure 2
Nature Neuroscience
6, 1292 - 1299 (2003)
Published online: 16 November 2003; | doi:10.1038/nn1157
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and foldingMarcy A Kingsbury, Stevens K Rehen, James J A Contos, Christine M Higgins
& Jerold Chun | | | | Figure 2. LPA induces cortical folds.
(a) Flowchart summarizing protocol for ex vivo culture. (b,c) Cresyl violet−stained sagittal sections of E14 hemispheres from the same animal showing extensive cortical folding after culture with LPA (c) compared to control medium (b). D, dorsal; R, rostral. Scale bars, 0.5 mm. (d,e) Whole-mount views of hemispheres following 17 h culture in control medium (d) or medium with LPA (e). The LPA-treated cortex shows cortical folds (arrowheads) that extend throughout the cerebral hemisphere. Overall circumferential dimensions of the cortex did not significantly change after LPA treatment (n = 9 matched pairs, P = 0.41, paired t-test).
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