Nature Neuroscience6, 1127 - 1134 (2003)
Published online: 28 October 2003; | doi:10.1038/nn1144
The glial identity of neural stem cells
Fiona Doetsch
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. Present address: Departments of Pathology and Neurology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA.
Glia are the most numerous cells in the brain, and their many diverse functions highlight their essential role in the nervous system. Recent studies have revealed an unexpected new role for glia in a wide variety of species, that of stem cells/progenitors in the adult and embryonic brain. Differentiation along the glial lineage may be a default state of development reflected in the progression of stem cells along the neuroepithelialradial gliaastrocyte lineage.
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