Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
Permissions
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
naturereprints
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews Neuroscience
Nature Cell Biology
Nature Medicine
Neuroscience Gateway
UCSD-Nature Signaling Gateway
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
Article
Nature Neuroscience  6, 1072 - 1078 (2003)
Published online: 31 August 2003; | doi:10.1038/nn1110


There is an Erratum (December 2003) associated with this Article.

NF-kappaB functions in synaptic signaling and behavior

Mollie K Meffert1, Jolene M Chang1, Brian J Wiltgen2, Michael S Fanselow2 & David Baltimore1

1  Division of Biology, MC204-31 California Institute of Technology, Pasadena, California 91125, USA.

2  Department of Psychology, 1285 Franz Hal, University of California Los Angeles, Los Angeles, California 90095, USA.

Correspondence should be addressed to David Baltimore baltimo@caltech.edu
Ca2+-regulated gene transcription is essential to diverse physiological processes, including the adaptive plasticity associated with learning. We found that basal synaptic input activates the NF-kappaB transcription factor by a pathway requiring the Ca2+/calmodulin-dependent kinase CaMKII and local submembranous Ca2+ elevation. The p65:p50 NF-kappaB form is selectively localized at synapses; p65-deficient mice have no detectable synaptic NF-kappaB. Activated NF-kappaB moves to the nucleus and could directly transmute synaptic signals into altered gene expression. Mice lacking p65 show a selective learning deficit in the spatial version of the radial arm maze. These observations suggest that long-term changes to adult neuronal function caused by synaptic stimulation can be regulated by NF-kappaB nuclear translocation and gene activation.

MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated

REVIEWS
NF-kappaB regulation in the immune system
Nature Reviews Immunology Review Article (01 Oct 2002)
 See all 2 matches for Reviews

NEWS AND VIEWS
Signal transduction: A cellular rescue team
Nature News and Views (06 Jul 2000)

RESEARCH
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
Oncogene Original Article (21 Mar 2002)
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells
Leukemia Original Article (24 Feb 2000)
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
The EMBO Journal Article (17 Mar 2003)
 See all 25 matches for Research

 Top
Abstract
Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

natureevents

Figures & Tables
Supplementary info
Export citation
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | Permissions | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | naturereprints | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2003 Nature Publishing Group | Privacy policy