Snip-snip, kill-kill: truncated SDF-1 and HIV-associated neurodegeneration
Richard M. Ransohoff
Richard Ransohoff is in the Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. ransohr@ccf.org
HIV-associated neurodegeneration likely involves release of signals from activated glial cells. A new study reveals that matrix metalloproteinase from HIV-1-infected macrophages or microglia cleaves the chemokine SDF-1 to generate a potent neurotoxin.
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REFERENCE Chemokines Nature Encyclopaedia of Life Sciences
