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Brief Communication
Nature Neuroscience 5, 727–728 (1 August 2002) | doi:10.1038/nn885
A phosphatidylinositol 3-kinase|[ndash]|phosphodiesterase 3B|[ndash]|cyclic AMP pathway in hypothalamic action of leptin on feeding
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Abstract
Using male Sprague-Dawley rats implanted with third intracerebroventricular (ICV) cannulae, we found that cilostamide, a phosphodiesterase 3 (PDE3) inhibitor, (i) reversed the established effects of leptin on food intake and body weight, (ii) blocked, at the hypothalamic level, the leptin-induced tyrosine phosphorylation of signal transducer and activator of transcription 3 (Stat3) and (iii) blocked the DNA binding of p-Stat3. Additionally, ICV administration of leptin increased hypothalamic phosphatidylinositol 3-kinase (PI3K) and PDE3B activities and decreased cyclic AMP (cAMP) concentration.
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