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Journal home Advance online publication Current issue Archive Press releases Supplements Focuses Guide to authors Online submission Permissions For referees Free online issue Contact the journal Subscribe Advertising work@npg naturereprints About this site For librarians   NPG Resources Nature Nature Reviews Neuroscience Nature Cell Biology Nature Medicine Neuroscience Gateway UCSD-Nature Signaling Gateway NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Brief Communication Nature Neuroscience  5, 719 - 720 (2002) Published online: 24 June 2002; | doi:10.1038/nn881 Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons Yan Zhu1, Tao Yu1, Xiao-Chun Zhang2, Takashi Nagasawa3, Jane Y. Wu2 & Yi Rao1 1  Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA 2  Department of Pediatrics, Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA 3  Department of Molecular and Cellular Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan Correspondence should be addressed to Jane Y. Wu jwu@pcg.wustl.edu or Yi Rao raoyi@thalamus.wustl.eduMigration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up the only precursor population known to migrate away from the surface of the brain. We studied the role of the chemokine stromal-derived factor 1 (SDF-1) in the cerebellar tissue of rats and knockout mice and found (i) that it functions as an attractive guidance cue for neuronal migration and (ii) that its secretion from non-neuronal meningeal tissue is important for controlling the migration of embryonic EGL cells. MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE Neuronal Migration Nature Encyclopaedia of Life Sciences  See all 4 matches for Reference REVIEWS Chemokine receptors: signposts to brain development and disease Nature Reviews Neuroscience Review (01 Jun 2003)  See all 6 matches for Reviews NEWS AND VIEWS Physiology: Chemokines beyond inflammation Nature News and Views (11 Jun 1998) Chemokines: back to the future? Nature Cell Biology News and Views (01 Feb 2001)  See all 3 matches for News And Views RESEARCH Nerve growth cone guidance mediated by G protein–coupled receptors Nature Neuroscience Article (01 Sep 2002)  See all 4 matches for Research  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Save this link Open Innovation Challenges Single-cell Analysis Platform Deadline: Dec 02 2009 Reward: $5,000 USD This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is... Optimizing Sub-cellular Localization Tags Deadline: Nov 29 2009 Reward: $20,000 USD The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression.... More Challenges Powered by: nature jobs Senior Scientific Manager / Chief Scientific Manager for Neuroscience Group In Vivo Pharmacology / Biology Syngene International Bangalore, Karnataka 560099 India Faculty Positions University of Texas Medical Branch Galveston, TX United States More science jobs Post a job for free Figures & Tables Supplementary info Export citation Search buyers guide:   ADVERTISEMENT

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