Nature Neuroscience5, 719 - 720 (2002)
Published online: 24 June 2002; | doi:10.1038/nn881
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
Yan Zhu1, Tao Yu1, Xiao-Chun Zhang2, Takashi Nagasawa3, Jane Y. Wu2
& Yi Rao1
1
Department of Anatomy and Neurobiology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA
2
Department of Pediatrics, Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8108, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA
3
Department of Molecular and Cellular Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan
Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up the only precursor population known to migrate away from the surface of the brain. We studied the role of the chemokine stromal-derived factor 1 (SDF-1) in the cerebellar tissue of rats and knockout mice and found (i) that it functions as an attractive guidance cue for neuronal migration and (ii) that its secretion from non-neuronal meningeal tissue is important for controlling the migration of embryonic EGL cells.
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