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Nature Neuroscience  5, 711 - 712 (2002)
doi:10.1038/nn0802-711

Mutant huntingtin goes straight to the heart

Elena Cattaneo1 & Paolo Calabresi2

1  Elena Cattaneo is in the Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133, Milano, Italy. elena.cattaneo@unimi.it

2  Paolo Calabresi is in the Department of Neuroscience, Clinica Neurologica, University of Rome Tor Vergata and I.R.C.C.S. Fondazione Santa Lucia, Roma, Italy. paolo.calabresi@uniroma2.it

New findings suggest that the mutant form of the huntingtin protein, which causes Huntington's disease, may damage neurons by directly interfering with mitochondrial function.

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REFERENCE
Huntington Disease
Nature Encyclopaedia of Life Sciences

REVIEWS
Experimental therapeutics in transgenic mouse models of Huntington's disease
Nature Reviews Neuroscience Review (01 May 2004)

NEWS AND VIEWS
Normal and mutant huntingtin: Partners in crime?
Nature Medicine News and Views (01 Nov 2000)
Hunting in the calm before the storm
Nature Genetics News and Views (01 Aug 2000)

RESEARCH
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Nature Neuroscience Article (01 Aug 2002)
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
Nature Medicine Article (01 Oct 1999)

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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