What a privilege to reside at the synapse: NMDA receptor signaling to CREB
Antonella Riccio
& David D. Ginty
The authors are in the Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, Maryland 21205-2185 ,USA. dginty@jhmi.edu
NMDA receptors are important for both normal transmission and pathological damage. New results indicate that receptor location makes the key difference: survival-promoting signals derive from synaptic receptors, whereas a cell-death signal comes from extrasynaptic receptors.
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