Two faces for an opioid peptide—and more receptors for pain research
Frédéric Simonin
& Brigitte L. Kieffer
The authors are at the IGBMC, 1 rue L:aurent Fires, 67400 Illkirch, France. briki@esbs.u-strasbg.fr
A new study reports the cloning of a family of 'orphan' G-protein-coupled receptors that are localized in human and rat small sensory neurons. These receptors are activated by a peptide derived from preproenkephalin A and may be involved in modulating nociception.
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