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Brief Communication
Nature Neuroscience 5, 95–96 (1 February 2002) | doi:10.1038/nn792
Neurofibromin regulates G protein|[ndash]|stimulated adenylyl cyclase activity
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Abstract
Neurofibromatosis type 1 (NF1) is a dominant genetic disorder characterized by multiple benign and malignant nervous system tumors, and by learning defects in 45% of children with NF1 mutations. Studies of neurofibromin, the protein encoded by NF1, have focused on its functions in tumorigenesis and regulation of Ras activity; however, Drosophila NF1 regulates both Ras and cyclic AMP (cAMP) pathways.
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