This supplement grew out of our curiosity about how neuroscience has contributed to improving the quality of people's lives. Fifteen review articles discuss recent progress toward a variety of practical applications of basic neuroscience, including memory enhancement, brain-computer interfaces, biotechnology of taste and smell, virtual reality, face recognition software, spinal cord injury and many others. In addition, five commentaries suggest ways to optimize the transfer of basic research to uses outside the laboratory. This special issue was supported by the National Institute of Neurological Disorders and Stroke and the National Institute on Drug Abuse.