Neuroprotective and neurorestorative strategies for Parkinson's disease
Ted M. Dawson1, 2, 3
& Valina L. Dawson1, 2, 3, 4
1
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
2
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
3
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
4
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Correspondence should be addressed to Ted M. Dawson tdawson@jhmi.edu
Advances in understanding the molecular mechanisms of cell death and the pathogenesis of sporadic and familial Parkinson's disease are creating new opportunities for the development of neuroprotective and/or neurorestorative therapies. Here we review many of these advances, highlighting areas and strategies that might be particularly suited to the development of innovative approaches that prevent degeneration and/or restore function in Parkinson's disease.
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