Dendritic spines show structural plasticity during development and in response to synaptic activity1,
2,
3. We previously found that EphB2 receptor tyrosine kinase, a receptor for B-ephrin ligands, is functionally involved in spine morphogenesis4, but the downstream signaling mechanisms are not known. Here we show that EphB2 physically associates with the guanine nucleotide exchange factor (GEF) intersectin and activates its GEF activity in cooperation with neural Wiskott-Aldrich syndrome protein (N-WASP), which in turn activates the Rho-family GTPase Cdc42 and spine morphogenesis.
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