Nature Neuroscience
4, 691 - 692 (2001)
doi:10.1038/89472
Cortical reorganization in motor cortex after graft of both handsPascal Giraux1, 2, Angela Sirigu1, Fabien Schneider3
& Jean-Michel Dubernard41
Institute for Cognitive Science, CNRS, 67 Bd Pinel, 69675 Bron, France
2
Department of Physical Medicine, CHU, BD Pasteur, Saint-Etienne
3
Radiology Department, CHU, BD Pasteur, Saint-Etienne
4
Department of Surgical Transplant, E. Herriot Hospital, Place d'Arsonval, Lyon
Correspondence should be addressed to Angela Sirigu sirigu@isc.cnrs.frCortical organization shifts after sensory deprivation, but the reversibility of this reorganization has not been studied. Here, using functional magnetic resonance imaging (fMRI), we investigated the dynamics of cortical reorganization in a patient's motor cortex before and after bilateral hand transplantation. We found that amputation-induced cortical reorganization was reversed following hand transplantation.
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