Nature Neuroscience
4, 685 - 686 (2001)
doi:10.1038/89460
Spine motility with synaptic contactAnna Dunaevsky1, 2, Richard Blazeski1, Rafael Yuste2
& Carol Mason11
Departments of Pathology, Anatomy and Cell Biology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, Room 14-509 P&S, 630 W. 168th Street, New York, New York 10032, USA
2
Department of Biological Sciences, Columbia University, 1002 Fairchild, New York, New York 10027, USA
Correspondence should be addressed to Anna Dunaevsky ad320@columbia.eduDendritic protrusions, including filopodia and spines, are highly dynamic1,
2,
3, but the extent to which their motility depends on afferent innervation or synaptic activity is under debate2,
3,
4,
5,
6,
7,
8. By monitoring dendritic spines of labeled Purkinje cells in cerebellar slices by two-photon microscopy, followed by ultrastructural analysis of the same imaged spines, we show that dendritic spines can exhibit morphological rearrangements even when they are contacted by presynaptic terminals.
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