PI-3 kinase and IP3: partners in NT3-induced synaptic transmission
David R. Kaplan1
& Ellis Cooper2
1
David Kaplan is in the Brain Tumor Research Center, Montreal Neurological Institute
2
Ellis Cooper is in the Department of Physiology, McGill University, Montreal, Quebec H3A 2B4, Canada. mcdv@musica.mcgill.ca
Neurotrophins are implicated in synaptic plasticity, but the signaling pathway was unknown. A new study shows that PI-3 kinase and IP3 are necessary and sufficient for NT3's actions.