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Review
Nature Neuroscience  3, 545 - 550 (2000)
doi:10.1038/75714

Synaptic plasticity and dynamic modulation of the postsynaptic membrane

C. Lüscher1, 2, 3, R. A. Nicoll4, 5, R. C. Malenka6 & D. Muller1

1  Department of Pharmacology (APSIC), CMU, 1, Rue Michel-Servet, Université de Genève, 1211 Geneva 4, Switzerland

2  Department of Physiology, Université de Genève, 1211 Geneva 4, Switzerland

3  Department of Neurology, Université de Genève, 1211 Geneva 4, Switzerland

4  Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Ave., San Francisco, California 94143, USA

5  Department of Physiology, University of California, San Francisco, 513 Parnassus Ave., San Francisco, California 94143, USA

6  Nancy Friend Pritzker Laboratory, Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94304-5485, USA

Correspondence should be addressed to C. Lüscher christian.luscher@medecine.unige.ch
The biochemical composition of the postsynaptic membrane and the structure of dendritic spines may be rapidly modulated by synaptic activity. Here we review these findings, discuss their implications for long-term potentiation (LTP) and long-term depression (LTD) and propose a model of sequentially occurring expression mechanisms.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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