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Article
Nature Neuroscience  3, 399 - 403 (2000)
doi:10.1038/73975

Prefrontal modulation of visual processing in humans

Francisco Barceló1, 2, Shugo Suwazono2, 3 & Robert T. Knight2

1  Department of Psychobiology, Faculty of Psychology, Complutense University, Somosaguas 28223, Madrid, Spain

2  Department of Psychology, University of California at Berkeley, 3210 Tolman Hall, Berkeley, California 94720-1650, USA

3  Department of Integrated Neuroscience, Brain Research Institute, Niigata University, Japan

Correspondence should be addressed to Robert T. Knight rtknight@socrates.berkeley.edu
Single neuron, evoked potential and metabolic techniques show that attention influences visual processing in extrastriate cortex. We provide anatomical, electrophysiological and behavioral evidence that prefrontal cortex regulates neuronal activity in extrastriate cortex during visual discrimination. Event-related potentials (ERPs) were recorded during a visual detection task in patients with damage in dorsolateral prefrontal cortex. Prefrontal damage reduced neuronal activity in extrastriate cortex of the lesioned hemisphere. These electrophysiological abnormalities, beginning 125 ms after stimulation and lasting for another 500 ms, were accompanied by behavioral deficits in detection ability in the contralesional hemifield. The results provide evidence for intrahemispheric prefrontal modulation of visual processing.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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