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Environmental factors are thought to be an important cause of Parkinson's disease. A new study shows that rats chronically treated with the mitochondrial inhibitor rotenone, a common pesticide, develop neuropathological and behavioral symptoms of Parkinsonism.
Llano and colleagues show that calcium released from presynaptic stores can drive simultaneous release of multiple vesicles at fast inhibitory synapses in the cerebellum.
AMPA, NMDA or insulin can cause endocytosis of AMPA receptors. Two papers now show that these stimuli act via distinct signaling pathways, some of which also induce LTD.
A recent Nature paper on mice lacking the Na+ channel BNC1 shows that this channel is essential for neuronal touch receptor function and may be part of a mechanosensory complex.
Practicing a procedural memory task does not improve performance until hours later. Two new studies show that sleep is absolutely necessary for this memory consolidation.
