 | Figure 1
Nature Neuroscience
3, 1227 - 1228 (2000)
doi:10.1038/81737
A new link between pesticides and Parkinson's diseaseBenoit I. Giasson
& Virginia M.-Y. Lee | | | | Figure 1. Possible mechanisms of selective cell death in Parkinson's and related diseases.
Mutations in  -synuclein may enhance its propensity to polymerize, resulting in the formation of inclusions that may comprise neuronal viability. Unidentified genetic mutations or polymorphisms may contribute directly to cell death or modulate the propensity of -synuclein to form inclusions, and they may also affect vulnerability to oxidative damage. Known mutations in genes such as UCH-L1 and parkin lead to the death of dopaminergic neurons, but it is unclear whether -synuclein pathology is involved. Environmental factors may also induce cell death, either directly or by initiating pathological cascades involving oxidative damage and -synuclein aggregation.
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