Caspases land on APP: One small step for apoptosis, one giant leap for
amyloidosis?
Rudolph E. Tanzi
Rudolph Tanzi is in the Department of Neurology, Harvard
Medical School, Massachusetts General Hospital, 149 13
th Street, Charleston, Massachusetts
02129, USA. tanzi@helix.mgh.harvard.edu
Gervais et al. suggest that caspase cleavage of amyloid precursor
protein (APP) may initiate a feedback loop that produces -amyloid deposits
in Alzheimer's disease.
-amyloid deposits
in Alzheimer's disease.
