 | Figure 2
Nature Neuroscience
2, 271 - 276 (1999)
doi:10.1038/6374
Impaired synaptic plasticity and learning in aged amyloid precursor protein
transgenic micePaul F. Chapman, Gail L. White, Matthew W. Jones, Deirdre Cooper-Blacketer, Vanessa J. Marshall, Michael Irizarry, Linda Younkin, Mark A. Good, T. V. P. Bliss, Bradley T. Hyman, Steven G. Younkin
& Karen K. Hsiao | | | | Figure 2. LTP is impaired in the dentate gyrus in aged APP695SWE transgenic
mice in vivo.
Following 20 minutes of baseline, theta-burst stimulation17
was delivered to the perforant pathway. Aged control mice demonstrated LTP
of both the fEPSP slope (b) and the population spike (c), whereas
transgenic mice showed only potentiation of the population spike, which was
nonetheless significantly smaller than controls. Representative responses
(a) demonstrate the degree of potentiation in transgenic (left) and non-transgenic
littermate control (right) brains, and also indicate the comparability of
baseline responses between transgenics and controls.
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