Selective gene expression increases behavioral sensitivity to cocaine
Steven E. Hyman
Steven E. Hyman is the Director of the National Institute
of Mental Health, National Institutes of Health, 6001 Executive
Boulevard, Room 8235, MSC 9669, Bethesda, Maryland
20892-9669, USA shyman@nih.gov
Addictive drugs induce a truncated form of fosB in the striatum. A new
study shows that mice engineered to mimic this expression pattern are abnormally
sensitive to cocaine.
