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A thorny question: how does activity maintain dendritic spines?

Nature Neuroscience volume 2, pages 5–7 (1999)Cite this article

Abstract

Most central excitatory synapses occur on dendritic spines. A new study shows that spine stability depends on spontaneous glutamate release and AMPA receptors.

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Figure 1: A dendritic spine synapse.

References

  1. Ramón y Cajal, S. Recollections of My Life (MIT Press, Cambridge, MA, 1989).

    Book  Google Scholar 

  2. Gray, E. G. J. Anat. (Lond.) 93, 420–433 (1959).

    CAS  Google Scholar 

  3. Andersen, P., Blackstad, T. W. & Lømo, T. Exp. Brain Res. 1, 236– 248 (1966).

    Article  CAS  Google Scholar 

  4. Matthews, D. A., Cotman, C. & Lynch, G. Brain Res. 115, 1– 21 (1976).

    Article  CAS  Google Scholar 

  5. Tanzi, E. Riv. Sper. Freniat. 19, 149 ( 1893).

    Google Scholar 

  6. Fischer, M., Kaech, S., Knutti, D. & Matus, A. Neuron 20, 847–854 (1998).

    Article  CAS  Google Scholar 

  7. Matus, A., Ackermann, M., Pehling, G., Byers, H. R. & Fujiwara, K. Proc. Natl. Acad. Sci. USA 79, 7590–7594 (1982).

    Article  CAS  Google Scholar 

  8. Morales, M. & Fifková, E. J. Comp. Neurol. 279, 666–674 (1989).

    Article  CAS  Google Scholar 

  9. Woolley, C. S., Gould, E., Frankfurt, M. & McEwen, B. S. J. Neurosci . 10, 4035–4039 ( 1990).

    Article  CAS  Google Scholar 

  10. Moser, M. B., Trommald, M. & Andersen, P. Proc. Natl. Acad. Sci. USA 91, 12673–12675 (1994).

    Article  CAS  Google Scholar 

  11. Trommald, M., Hulleberg, G. & Andersen, P. Learn. Mem. 3, 218– 228 (1996).

    Article  CAS  Google Scholar 

  12. Collin, C., Miyaguchi, K. & Segal, M. J. Neurophysiol. 77, 1614– 1623 (1997).

    Article  CAS  Google Scholar 

  13. Vicario–Abejon, C., Collin, C., McKay, R. D. & Segal, M. J. Neurosci. 18, 7256–7271 (1998).

    Article  Google Scholar 

  14. Murphy, D. D. & Segal, M. Proc. Natl. Acad. Sci. USA 94, 1482–1487 (1997).

    Article  CAS  Google Scholar 

  15. Wang, Y., Small, D. L., Stanimirovic, D. B., Morley, P. & Durkin, J. P. Nature 389, 502–504 (1997).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurophysiology, Institute for Basic Medical Sciences, University of Oslo, Pb 1103, Oslo, 0317, Blindem, Norway

    Per Andersen & Anne Figenschou Soleng

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  1. Per Andersen
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  2. Anne Figenschou Soleng
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Andersen, P., Soleng, A. A thorny question: how does activity maintain dendritic spines?. Nat Neurosci 2, 5–7 (1999). https://doi.org/10.1038/4506

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