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Nature Neuroscience  2, 3 - 5 (1999)
doi:10.1038/4503

Silent synapses: I can't hear you! Could you please speak aloud?

Antonio Malgaroli

Antonio Malgaroli is at the Unit of Neurobiology of Learning, Scientific Institute San Raffaele,Via Olgettina 58, Milano 20132, Italy.
malgaroli.antonio@mail.hsr.it

Cyclic AMP application mimics the late phase of long-term potentiation in hippocampal CA3−CA1 cultures. Now imaging with FM1-43 shows that this activity-dependent change in synaptic strength involves the recruitment of pre-existing, presynaptically silent synapses.

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Nature Neuroscience
ISSN: 1097-6256
EISSN: 1546-1726
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