During cocaine withdrawal, a shift in the balance between excitatory and inhibitory inputs from globus pallidus to lateral habenula may activate habenula and contribute to the aversive 'crash' state.
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Ishikawa, M., Kenny, P. Crash course in pallidus–habenula signaling. Nat Neurosci 19, 981–983 (2016). https://doi.org/10.1038/nn.4349
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DOI: https://doi.org/10.1038/nn.4349