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Astrocyte endfeet march to the beat of different vessels

During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation.

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Figure 1: The functions of astrocyte endfeet differ with respect to the vascular target.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Serge Charpak.

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Rungta, R., Charpak, S. Astrocyte endfeet march to the beat of different vessels. Nat Neurosci 19, 1539–1541 (2016). https://doi.org/10.1038/nn.4446

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