Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Go with your gut: microbiota meet microglia

Discovering the environmental factors that control microglia is key to understanding and managing brain health. A new study finds that microbiota in the gut are essential to the regulation of microglial maturation and activation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Communication from gut to brain regulates microglia.

Kim Caesar/Nature Publishing Group

References

  1. Ley, R.E. et al. Science 320, 1647–1651 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Diaz Heijtz, R. et al. Proc. Natl. Acad. Sci. USA 108, 3047–3052 (2011).

    Article  PubMed  Google Scholar 

  3. Clarke, G. et al. Mol. Psychiatry 18, 666–673 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Mayer, E.A. Nat. Rev. Neurosci. 12, 453–466 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Erny, D. et al. Nat. Neurosci. 18, 965–977 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kierdorf, K. et al. Nat. Neurosci. 16, 273–280 (2013).

    CAS  PubMed  Google Scholar 

  7. Ginhoux, F. et al. Science 330, 841–845 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kettenmann, H., Hanisch, U.-K., Noda, M. & Verkhratsky, A. Physiol. Rev. 91, 461–553 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. Nikodemova, M. et al. J. Neuroimmunol. 278, 280–288 (2015).

    Article  CAS  PubMed  Google Scholar 

  10. Perry, V.H., Hume, D.A. & Gordon, S. Neuroscience 15, 313–326 (1985).

    Article  CAS  PubMed  Google Scholar 

  11. Schafer, D.P. et al. Neuron 74, 691–705 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Braniste, V. et al. Sci. Transl. Med. 6, 263ra158 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Mildner, A. et al. Nat. Neurosci. 10, 1544–1553 (2007).

    CAS  PubMed  Google Scholar 

  14. Grenham, S., Clarke, G., Cryan, J.F. & Dinan, T.G. Frontiers Physiol. 2, 94 (2011).

    Article  Google Scholar 

  15. Ng, K.M. et al. Nature 502, 96–99 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tony Wyss-Coray.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mosher, K., Wyss-Coray, T. Go with your gut: microbiota meet microglia. Nat Neurosci 18, 930–931 (2015). https://doi.org/10.1038/nn.4051

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.4051

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing