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Transcriptional architecture of the human brain

Nature Neuroscience volume 18, pages 1699–1701 (2015)Cite this article

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The largest survey of gene expression ever performed in the adult human brain reveals highly stereotyped transcriptional patterning across individuals. The most stably patterned genes are enriched for neuronal annotations, disease associations, drug targets and correspond to resting state functional networks.

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Figure 1: Generating and analyzing the Allen Human Brain Atlas.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Kevin W. Kelley is with the Medical Scientist Training Program and Neuroscience Graduate Program, University of California San Francisco, San Francisco, California, USA,

    Kevin W Kelley

  2. Michael C. Oldham is in the Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.,

    Michael C Oldham

Authors
  1. Kevin W Kelley
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  2. Michael C Oldham
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Correspondence to Michael C Oldham.

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The authors declare no competing financial interests.

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Kelley, K., Oldham, M. Transcriptional architecture of the human brain. Nat Neurosci 18, 1699–1701 (2015). https://doi.org/10.1038/nn.4178

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