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The cellular target of antidepressants

The serotonin 1A receptor expressed on mature granule cells in the dentate gyrus mediates the behavioral, neurogenic and endocrine effects of the antidepressant fluoxetine in the mouse.

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Figure 1: Mature granule cells in the dentate gyrus mediate the effects of the antidepressant fluoxetine.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Nicholas J Brandon or Ron McKay.

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N.J.B. is employed by, and a shareholder in, AstraZeneca.

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Brandon, N., McKay, R. The cellular target of antidepressants. Nat Neurosci 18, 1537–1538 (2015). https://doi.org/10.1038/nn.4144

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