New findings in preclinical Alzheimer's disease patients and mouse models of the disease suggest that it is the lateral, rather than the medial, entorhinal cortex that is most susceptible to tau pathology early in Alzheimer's disease. Aberrations begin here and spread to other cortical sites.
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Yassa, M. Ground zero in Alzheimer's disease. Nat Neurosci 17, 146–147 (2014). https://doi.org/10.1038/nn.3631
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DOI: https://doi.org/10.1038/nn.3631
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