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A finely tuned cortical amplifier

Three studies in visual and auditory cortex show that intracortical excitatory inputs amplify incoming sensory signals, as their sensory tuning is closely matched to that arriving from the sensory thalamus.

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Figure 1: Dissecting the contributions of thalamocortical and intracortical excitation to total excitation in layer 4 neurons in mouse visual cortex.

References

  1. da Costa, N.M. & Martin, K.A. J. Comp. Neurol. 516, 264–276 (2009).

    Article  Google Scholar 

  2. Jin, J., Wang, Y., Swadlow, H.A. & Alonso, J.M. Nat. Neurosci. 14, 232–238 (2011).

    Article  CAS  Google Scholar 

  3. Reid, R.C. & Alonso, J.M. Nature 378, 281–284 (1995).

    Article  CAS  Google Scholar 

  4. Ferster, D., Chung, S. & Wheat, H. Nature 380,, 249–252 (1996).

    Article  CAS  Google Scholar 

  5. Chung, S. & Ferster, D. Neuron 20, 1177–1189 (1998).

    Article  CAS  Google Scholar 

  6. Douglas, R.J., Koch, C., Mahowald, M., Martin, K.A. & Suarez, H.H. Science 269, 981–985 (1995).

    Article  CAS  Google Scholar 

  7. Gilbert, C.D. & Wiesel, T.N. J. Neurosci. 9, 2432–2442 (1989).

    Article  CAS  Google Scholar 

  8. Ko, H. et al. Nature 473, 87–91 (2011).

    Article  CAS  Google Scholar 

  9. Li, L., Li, Y., Zhou, M., Tao, H.W. & Zhang, L.I. Nat. Neurosci. 16, 1179–1181 (2013).

    Article  CAS  Google Scholar 

  10. Li, Y., Ibrahim, L.A., Liu, B., Zhang, L.I. & Tao, H.W. Nat. Neurosci. 16, 1324–1330 (2013).

    Article  CAS  Google Scholar 

  11. Lien, A.D. & Scanziani, M. Nat. Neurosci. 16, 1315–1323 (2013).

    Article  CAS  Google Scholar 

  12. Ko, H. et al. Nature 496, 96–100 (2013).

    Article  CAS  Google Scholar 

  13. Scholl, B., Tan, A.Y.Y., Corey, J. & Priebe, N.J. J. Neurosci. 33, 10616–10624 (2013).

    Article  CAS  Google Scholar 

  14. Piscopo, D.M., El-Danaf, R.N., Huberman, A.D. & Niell, C.M. J. Neurosci. 33, 4642–4656 (2013).

    Article  CAS  Google Scholar 

  15. Marshel, J.H., Kaye, A.P., Nauhaus, I. & Callaway, E.M. Neuron 76, 713–720 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Thomas Mrsic-Flogel.

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Han, Y., Mrsic-Flogel, T. A finely tuned cortical amplifier. Nat Neurosci 16, 1166–1168 (2013). https://doi.org/10.1038/nn.3507

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