The onset of puberty in mammals is determined by a poorly understood mix of genetics and environment. A survey of the epigenetic methylation landscape provides insight into a potential mechanism for the onset of puberty in females involving emancipation from a repressive gene complex in hypothalamic neurons.
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McCarthy, M. A piece in the puzzle of puberty. Nat Neurosci 16, 251–253 (2013). https://doi.org/10.1038/nn.3339
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DOI: https://doi.org/10.1038/nn.3339
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