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A piece in the puzzle of puberty

The onset of puberty in mammals is determined by a poorly understood mix of genetics and environment. A survey of the epigenetic methylation landscape provides insight into a potential mechanism for the onset of puberty in females involving emancipation from a repressive gene complex in hypothalamic neurons.

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Figure 1: Epigenetic repression of puberty.

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Correspondence to Margaret M McCarthy.

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McCarthy, M. A piece in the puzzle of puberty. Nat Neurosci 16, 251–253 (2013). https://doi.org/10.1038/nn.3339

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